ACYCLOVIR

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Trade registered name: Zovirax

Function (Antiretroviral Drugs)

It is a drugs produce to treat herpes simplex viral   and varicella zoster infection.

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Usage

It is used to the following;

  1.  Occurrences in a short term interval and long terms oral and oesophageal herpes virus in immunocompromised patients.
  2. Genital herpes
  3. Herpetic kerato uveitis
  4. Severe case of zoster, such as necrosis or extensive forms, facial or ophthalmic zoster

It also used as a preventive agent in patient with recurrence in a short term interval or severe recurrence

Availability

Come in 200mg and 800mg tablets

40mg/ml oral suspension

Prescription

  1. Occurrences in a short term interval and long terms oral and oesophageal herpes virus in immunocompromised patients.
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Children under 2 years should be given 200mgs/days in 5 divided doses for 7 days

Children above 2 years and adult should be given 400mg/day in 5 divided dose for 7 days

  1. Genital herpes

Children above 2 years and adult should be given 400mg/day in 3 divided dose for 7 days

For immunocompromised patients, the treatment should be continue until clinical resolution.

  1. It also used as a preventive agent in patient with recurrence in a short term interval or severe recurrence

Children bellow 2 years, should be given 200mg/days in 2 divided doses

Children above 2 years and adult should be given 400mg/day in 2 divided dose

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20kg,  should be given 50  100mg/kg/day in 4 divided doses, and should not exceed 100mg/kg/day.

Adult 3 to 6g/day in 4 divided doses, and should not exceed 6g/day

  1. Severe case of zoster, such as necrosis or extensive forms, facial or ophthalmic zoster

Adult should be given 800mg/day in 5 divided dose for 7 days.

Precautions

Never administer acyclovir  to patient that is hypertensive to the drugs

The administering dose should be reduce in a patient with renal impairment

Make sure the patient take a lot of water when on treatment with acyclovir.

Adverse Effect

  1. Headache
  2. Skin rash
  3. Allergic reaction
  4. Gastrointestinal disturbance
  5. Hematological disorder
  6. Elevate transaminase
  7. Disorder of neurologic in a patient elderly patient and patient with renal impairment.
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Advice

Pregnancy: no contra-indication

Breast feeding: no contra indication

Acyclovir should be started earlier for treatment of herpes simplex possible 90 hours after the one set appearance of the lesion, it help to reduce duration of the infection also reduce the severity.

A treatment of herpes zoster should be commenced preferable 70 hours after the one set of the lesion

Store the drugs at temperature bellow 25ºC.

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